Characterization of chloride intracellular channel 4 in the regulation of human trophoblast function

W Zhou; E Menkhorst; E Dimitriadis

Journal article

Characterization of chloride intracellular channel 4 in the regulation of human trophoblast function

W Zhou, E Menkhorst, E Dimitriadis

Placenta | W B SAUNDERS CO LTD | Published : 2022

DOI: 10.1016/j.placenta.2022.01.012

Abstract

Introduction: Proper placentation requires well controlled extravillous trophoblast cell (EVT) migration and invasion. Transforming growth factor β (TGFβ) signaling has been well characterized as negatively regulating EVT migration and invasion. CLIC4 is an enhancer of TGFβ signaling, however CLIC4's function in placentation and its association to placental TGFβ signaling is unknown. Here we aimed to investigate the role of CLIC4 on trophoblast cell function and its relationship to TGFβ signaling. Methods: CLIC4 was immunolocalized in human placenta throughout gestation and the first trimester decidua. siRNA was used to knockdown CLIC4 in a human trophoblast cell line (HTR8/SVneo) to reveal ..

View full abstract

University of Melbourne Researchers

Wei Zhou Author

Ellen Menkhorst Author

Evdokia Dimitriadis, Eva Dimitriadis Author

Related Projects (1)

CRITICAL REGULATORS OF PLACENTATION

The placenta is essential for fetal-maternal exchange and healthy pregnancy however the factors that are required for the placenta to form a..

Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

NHMRC (Australia) project grant (GNT1098332) and Fellowship (#550905; E. D) . E.M. was supported by a Mid-Career Fellowship, Department of Obstetrics and Gynecology, The University of Melbourne.